MLB Best Bets Saturday 4/5/25

Hey everyone! Welcome back to the grind—it’s Saturday, April 5th, and we’ve got a loaded MLB slate to dig into.

I’m pumped after a 6-0 sweep last night, and today’s matchups are ripe with betting opportunities. I’ve broken down the key games, spotlighted the top players, and locked in my best bets for this slate.

Let’s keep the momentum rolling and cash some tickets together! Here’s what I’m seeing across today’s games, with detailed insights and my favorite bets.

Check out our Free Prop Projections
Prop Projections | Prizepicks Projections | Underdog Projections

Key Matchups and Best Bets

1. Detroit Tigers vs. Chicago White Sox (1:10pm ET, Comerica Park)

Matchup Insights: Reese Olson takes the mound for the Tigers against Davis Martin of the White Sox. Olson’s first start wasn’t dazzling (4.2 IP, 4 ER vs. LAD), but he’s got a 23.1% K% vs. lefties and a stingy .091 ISO allowed vs. righties. Martin, meanwhile, shoved against the Angels (6 IP, 0 ER), but that offense isn’t on par with Detroit’s upside. The Tigers’ lineup—featuring Kerry Carpenter (.319 ISO vs. RHP) and Riley Greene (.233 ISO)—should feast on Martin’s 19.3% K% and .133 ISO allowed vs. righties. Comerica’s neutral park factors (50°, humid) won’t suppress this offense.

Why Carpenter’s a Best Bet: Carpenter’s a lefty masher with a .401 xwOBA and insane power against right-handers like Martin. His recent form suggests he’s locked in, and Martin’s lack of swing-and-miss stuff (19.3% K%) leaves the door open for extra-base hits. This is a prime spot for Carpenter to go yard or rack up RBIs.

Suggested Bet: Kerry Carpenter Over 1.5 Hits + Runs + RBIs (-115)
- Carpenter’s power and Martin’s hittable stuff make this a juicy prop at near-even money.

2. Houston Astros vs. Minnesota Twins (2:10pm ET, Target Field)

Matchup Insights: Spencer Arrighetti (HOU) faces Bailey Ober (MIN). Arrighetti looked sharp in his debut (6 IP, 1 ER vs. NYM), boasting a 28.7% K% vs. lefties—perfect against Twins like Matt Wallner (.265 ISO). Ober, however, got torched by St. Louis (2.2 IP, 8 ER), with a .204 ISO allowed vs. righties that Houston’s lineup (Altuve, Alvarez) can exploit. Target Field’s pitcher-friendly conditions (40°, 14mph wind) might keep totals down, but Houston’s bats have an edge.

Why Alvarez’s a Best Bet: Yordan Alvarez is a beast against righties (.249 ISO, .409 xwOBA), and Ober’s tendency to leave fastballs high in the zone plays right into his wheelhouse. After a slow start, Alvarez showed signs of life two games ago, and this matchup screams breakout. Ober’s 27.4% K% is solid, but Alvarez’s 14.1% K% keeps him in play.

Suggested Bet: Yordan Alvarez Over 1.5 Hits + Runs + RBIs (-120)
- Alvarez’s power and Ober’s struggles make this a high-probability cash.

3. San Diego Padres vs. Chicago Cubs (2:20pm ET, Wrigley Field)

Matchup Insights: Nick Pivetta (SD) battles Matthew Boyd (CHC). Pivetta dominated Atlanta (7 IP, 1 H), with a 30.2% K% vs. lefties that’ll challenge Cubs like Kyle Tucker (.367 ISO). Boyd was solid vs. Arizona (5 IP, 0 ER), but his 7.8% BB% vs. righties could haunt him against San Diego’s right-handed core (Tatis, Machado). Wrigley’s wind (13mph) might suppress power, but the Padres’ pitch-specific strengths (e.g., #1 vs. sliders) align with Boyd’s mix.

Why Tatis Jr.’s a Best Bet: Fernando Tatis Jr. thrives against lefties (.374 xwOBA), and Boyd’s fastball-heavy approach (with a .230 avg allowed vs. righties) sets up Tatis for success. His 25.4% K% vs. LHP is manageable, and a low walk prop fits Boyd’s profile—he’s not wild enough to miss the zone consistently.

Suggested Bet: Fernando Tatis Jr. Under 0.5 Walks (-155)
- Tatis either hits or strikes out here, and Boyd’s control keeps walks low.

4. Arizona Diamondbacks vs. Washington Nationals (4:05pm ET, Nationals Park)

Matchup Insights: Eduardo Rodriguez (ARI) squares off against Mitchell Parker (WSH). Rodriguez struggled vs. CHC (5.1 IP, 3 ER), but his .217 ISO allowed vs. righties matches up well against a Nationals lineup with limited pop (e.g., Ruiz .118 ISO). Parker was lights-out vs. PHI (6.1 IP, 0 ER), but Arizona’s righties (Grichuk .218 ISO, Gurriel Jr. .189 ISO) crush lefties. Nationals Park (72°, humid) is neutral, favoring bats slightly.

Why Grichuk’s a Best Bet: Randal Grichuk’s .385 xwOBA and .218 ISO vs. LHP make him a nightmare for Parker, who allows a .167 ISO to righties. Grichuk’s low 16.8% K% vs. lefties ensures he puts the ball in play, and Parker’s fastball-splitter mix plays into Arizona’s strengths.

Suggested Bet: Randal Grichuk Over 1.5 Hits + Runs + RBIs (-110)
- Grichuk’s contact and power make this a steal against Parker.

5. Los Angeles Dodgers vs. Philadelphia Phillies (4:05pm ET, Citizens Bank Park)

Matchup Insights: Roki Sasaki (LAD) faces Aaron Nola (PHI). Sasaki’s MLB sample is tiny (1.2 IP, 33.3% BB% vs. RHP), but his overseas pedigree suggests upside against a Phillies lineup with K-prone bats (Schwarber 28.9%). Nola got lit up by WSH (high ERA implied), but his 27.3% K% vs. RHP can exploit Dodgers like Hernandez (29.4%). Citizens Bank Park (56°, humid) boosts offense, setting up a slugfest.

Why Ohtani’s a Best Bet: Shohei Ohtani’s .396 ISO and .468 xwOBA vs. RHP are absurd, and Nola’s .203 ISO allowed vs. lefties is a crack he can exploit. Ohtani’s multi-position eligibility doesn’t matter here—his bat does. This is a home run or bust spot.

Suggested Bet: Shohei Ohtani Over 1.5 Hits + Runs + RBIs (-125)
- Ohtani’s elite stats and Nola’s vulnerability scream value.

6. New York Yankees vs. Pittsburgh Pirates (4:05pm ET, PNC Park)

Matchup Insights: Marcus Stroman (NYY) takes on Bailey Falter (PIT). Stroman’s 18.9% K% vs. RHP isn’t elite, but Pittsburgh’s offense is anemic (Hayes .042 ISO). Falter’s 16.9% K% vs. RHP is worse, and the Yankees’ righties (Judge .496 ISO vs. LHP) should tee off. PNC Park (68°, humid) is neutral, but New York’s power tilts this.

Why Judge’s a Best Bet: Aaron Judge is a lefty-killer (.496 ISO, .509 xwOBA vs. LHP), and Falter’s fastball-slider mix is meat on a platter. Judge’s 23.8% K% vs. lefties is fine—he’s hitting bombs here.

Suggested Bet: Aaron Judge Over 1.5 Hits + Runs + RBIs (-130)
- Judge’s dominance vs. lefties makes this a lock.

Key Slate Takeaways

Pitching Edges: Pivetta (SD) and Arrighetti (HOU) stand out with high K% and favorable matchups. Fade Ober (MIN) and Falter (PIT) due to hittable stuff.
Offensive Hotspots: Dodgers, Astros, and Yankees have the best upside against shaky starters. Tigers and Diamondbacks offer value vs. weaker arms.
Weather Watch: Wrigley (13mph wind) and Target Field (14mph) could cap totals, while Citizens Bank (56°) and PNC (68°) favor bats.

Ready to turn these insights into wins?

Maximize your betting and fantasy picks with Oddsjam—the ultimate tool for finding reliable bets fast. Check it out here.

With features like Promo Finder, Arbitrage Bets, Positive EV Bets, and a 7-day free trial, you’ll unlock your betting potential with industry-leading tools.